Generic Name: Monobenzone

Brand Name: Benoquin

 

PHARMACOLOGY

 

Monobenzone 20% cream bearing the brand name Benoquin is a depigmenting agent and particularly used to treat Vitiligo, a type of skin disorder. Its mechanism of action is yet to be fully comprehended. When this topical treatment is applied to animals, it intensifies the excretion of melanin from the melanocytes (the cells that make melanin). The same action is believed to be behind the depigmenting effect of the medication in human beings. Benoquin (Monobenzone) may induce the complete elimination of melanocytes and permanent depigmentation of the skin. The outcome of this drug is quite unpredictable and may take 1 to 4 months to happen.

 

The depigmentation process with topical Monobenzone does not alter the histology of the skin. It remains the same as that observed in Vitiligo. The epidermis or the outer layer of the skin is normal too with the exception of the nonexistence of recognizable melanocytes. So, the role of Benoquin is to permanently discolor the normal skin around vitiliginous lesions solely in patients who have propagated (above 50 percent of body surface area) idiopathic Vitiligo.

 

INDICATIONS AND USAGE

 

Benoquin (Monobenzone) cream 20% is indicated for permanent depigmentation in widespread Vitiligo. It is topically applied to the normal skin surrounding the white patches in patients with disseminated Vitiligo arising from an unknown cause. Benoquin cream is not prescribed for freckles, hyperpigmentation occurred due to photosensitization after the use of certain perfumes or hyperpigmentation arising from inflammation of the skin, or mask of pregnancy (chloasma). It is also not recommended as an effective treatment for malignant melanoma, cafe-au-lait spots, pigmented nevi, or pigmentation resulting from pigments other than melanin, such as silver, bile or artificial pigments.

 

DOSAGE AND ADMINISTRATION

 

As a topical therapy, Benoquin (Monobenzone) cream should be applied and rubbed into the normal pigmented skin area in a thin layer uniformly. You must use the medication twice or thrice a day, or as prescribed by your healthcare provider. Direct exposure to sunlight should be avoided for a prolonged period of time. Never forget to apply a quality sunscreen lotion over your body when you go outside. You can cover your body with protective clothing too.

 

You’ll start to experience depigmentation after one to four months depending on your skin darkness and regular use. If you don’t get the desired results using Benoquin (Monobenzone) cream after four months, the medication should be discontinued. Once you obtain the desired level of depigmentation, you can use the cream twice a week only to sustain the effect of depigmentation. Store the drug at a safe place and out of the reach of children. If somebody consumes it accidentally, call a doctor or a Poison Control Center right away.

 

CONTRAINDICATIONS

 

Benoquin (Monobenzone) cream 20% is a powerful depigmenting agent that generates permanent discoloration of the skin. You should never use it as a mild cosmetic bleaching agent. The medication is contraindicated in all conditions other than disseminated Vitiligo. Benoquin is not an alternative for hydroquinone creams. Monobenzone is also contraindicated in patients who have known hypersensitivity to this drug or any of its ingredients.